用于长期冠状动脉疾病患者的sirolimus-eluting支架与paclitaxel-eluting支架
Young-Hak Kim1, Seong-Wook Park, Seung-Whan Lee
1Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Circulation
|October 25, 2006
概括
与帕克利塔塞尔排泄支架 (PES) 相比,在长期冠状动脉病变中,西罗利斯排泄支架 (SES) 显著降低了复缩和再血管化需求. 这一发现为为复杂病变进行冠状动脉干预的患者提供了更好的结果.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 生物材料科学 生物材料科学
背景情况:
- 对长期病变的冠状动脉干预具有低于最佳的结果.
- 释放药物的支架旨在改善这些结果.
- 通常使用的是西洛利斯排泄支架 (SES) 和帕克利塔塞尔排泄支架 (PES).
研究的目的:
- 为了比较SES与PES在治疗长期本土冠状动脉病变方面的疗效.
- 为了评估复缩率和需要再血管化的需要.
主要方法:
- 这是一项随机,多中心,前性研究,涉及500名患者.
- 患者在长时间冠状动脉病变 (>=25毫米) 时接受SES或PES治疗.
- 主要终点是6个月后的随访血管造影时的细分内静止症.
主要成果:
- 与PES相比,SES显示了相对较低的分段内二元缩率 (3.3%与14.6%,P<0.001).
- 在静脉支架中,晚期光损失在SES (0.09毫米与0.45毫米相比,P<0.001) 中显著降低.
- 9个月后,SES组的目标损伤重血管化率降低 (2.4%对7.2%,P=0.012).
结论:
- 在长期的本土冠状动脉病变中,SES植入优于PES.
- SES 减少了血管学复缩和需要目标损伤再血管化的需要.
- 两组之间死亡率或心肌梗塞率没有显著差异.
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