在心肌输液研究中使用的被污染的放射性药物引起的C型肝炎病毒感染
Priti R Patel1, A Kirsten Larson, Amanda D Castel
1Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA. ppatel@cdc.gov
JAMA
|October 26, 2006
概括
十六名患者感染了型肝炎病毒 (HCV) 感染,感染的原因是心输液研究中使用的被污染的放射性药物. 不安全的药房实践,包括针头重复使用,导致了疫情爆发,突出了严格的无菌技术的需要.
科学领域:
- 传染性疾病 传染性疾病
- 核制药公司 核制药公司
- 流行病学 流行病学
背景情况:
- 核药房准备放射性药物用于诊断成像,如心肌 perfusion 研究.
- 型肝炎病毒 (HCV) 传播在核成像设置中以前没有被记录.
研究的目的:
- 在接受心肌输液研究的患者中调查急性HCV感染的爆发.
- 在核药房环境中确定HCV的来源和传播途径.
主要方法:
- 进行了疫情调查,包括分子流行病学和药房现场审查.
- 对接受放射性药物治疗的90名患者进行了血液传递病原体检测.
- 进行HCV准物种分析,以比较患者和来源样本.
主要成果:
- 确定了16名急性HCV感染患者,所有患者都与单个放射性药物瓶有关.
- 来自病例的HCV准物种序列几乎与来自潜在源患者的序列相同.
- 确定药房的做法,如针头重复使用和共享设备作为潜在的交叉污染来源.
结论:
- 十六个人因血液污染的放射性药物感染HCV感染.
- 在核药房确定了无菌技术的来源和漏洞.
- 核药房在处理生物产品时必须遵守无菌技术,以防止无菌放射性药物污染.
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