在童年动脉缺血性中风后的临床和放射性复发
Vijeya Ganesan1, Mara Prengler, Angela Wade
1Neurosciences Unit, Institute of Child Health, University College London, London, United Kingdom. v.ganesan@ich.ucl.ac.uk
Circulation
|November 1, 2006
概括
在儿童期动脉缺血性中风 (AIS) 后,临床和放射性复发是常见的. 莫亚莫亚病和遗传性血栓友病增加了临床复发风险,而先前的诊断和白细胞病则与放射性复发有关.
科学领域:
- 儿科神经学 儿科神经学
- 神经科学是一个神经科学.
- 血管神经学 血管神经学
背景情况:
- 儿童动脉缺血性中风 (AIS) 复发率和风险因素对于制定二次预防策略至关重要.
- 了解复发模式可以为儿科中风的临床管理和研究方向提供信息.
研究的目的:
- 调查与儿童第一次动脉缺血性中风 (AIS) 后临床和放射性复发相关的发病率和风险因素.
- 确定预测复发的特定患者特征和条件,帮助有针对性的二次预防.
主要方法:
- 在1978年至2000年间诊断出首次AIS的儿科患者的回顾性和前性鉴定.
- 使用Cox和后勤回归模型分析临床复发 (中风,TIA,死亡) 和放射性复发 (复发性心脏病发作).
- 包括神经成像数据,病史和实验室发现 (例如,遗传性血栓,白细胞病) 以确定相关的风险因素.
主要成果:
- 在AIS后11.5年内,79名儿童经历了临床复发 (中风,TIA或死亡);5年无复发生存率为59%.
- 莫亚莫亚病和低出生体重是整体队列中临床复发的独立预测因素.
- 在以前健康的儿童中,遗传血栓友预测了临床复发. 在179名患者中,60名患者发生了放射性再发作,先前的TIA,双边心脏病发作,免疫缺陷和白细胞瘤是显著的危险因素.
结论:
- 临床和放射性复发是儿童AIS后经常发生的情况.
- 莫亚莫亚病和遗传血栓形成症是儿科AIS临床复发的关键危险因素.
- 以前存在的疾病,如免疫缺陷和白细胞数量升高 (白血球症) 与放射性复发有关,这表明潜在的感染或炎症联系.
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