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相关概念视频

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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相关实验视频

Updated: May 8, 2026

A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

在心血管疾病中的刺形态原体.

Maarten F Bijlsma1, Maikel P Peppelenbosch, C Arnold Spek

  • 1Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Circulation
|November 1, 2006
PubMed
概括

刺 (Hh) 蛋白家族对发育至关重要. 本综述探讨了Hh信号在心血管发育中的作用,并提出了低密度脂蛋白 (LDL) 在Hh传输中的新作用.

科学领域:

  • 发育生物学 发展生物学
  • 分子生物学分子生物学
  • 心血管研究研究心血管研究

背景情况:

  • 刺 (Hh) 蛋白家族在胚胎发育中起着根本性的作用.
  • Hh信号通路调节细胞生长,分化和组织模式.
  • Hh信号的失调与各种疾病有关,包括心血管疾病.

研究的目的:

  • 为了审查子 (Hh) 蛋白家族的基本生物学和发育功能.
  • 详细介绍心血管发育中的Hh信号及其在缺血中的作用.
  • 提出一种新的Hh运输机制,涉及低密度脂蛋白 (LDL).

主要方法:

  • 关于对 (Hh) 信号的现有研究的文献综述.
  • 对基因发现,命名和通路机制的分析.
  • 讨论与心血管发育和缺血模型相关的Hh信号的最新发现.

主要成果:

  • 刺 (Hh) 蛋白家族对各种发育过程至关重要.
  • Hh信号对于心血管发育至关重要,在缺血病研究中显示出有前途.
  • 提出了一个低密度脂蛋白 (LDL) 中介哺乳动物Hh运输的假设.

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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

相关实验视频

Last Updated: May 8, 2026

A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

结论:

  • 刺 (Hh) 蛋白质是重要的发育调节剂,在心血管健康中起着重要作用.
  • 低密度脂蛋白 (LDL) 可能成为哺乳动物中Hh蛋白的新型载体.
  • 这种潜在的LDL-Hh相互作用为了解和治疗心血管疾病开辟了新的途径.