调整具有五芳香功能的类二次结构:用于构建离散折叠的类结构的新设计范式
Benjamin C Gorske1, Helen E Blackwell
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1322, USA.
Journal of the American Chemical Society
|November 2, 2006
概括
研究人员探索了五芳基团如何影响peptoid结构. 引入一种特定的化单体 (S) -N-{1-{pentafluorophenyl (ethyl) glycine) 可以控制类是否形成循环或螺旋.
科学领域:
- 聚合物化学 聚合物化学
- 超分子化学 超分子化学
- 有机合成 有机合成
背景情况:
- 化物 (N替代的甘氨酸寡合物) 模仿天然,对研究生物分子相互作用和开发仿生学有价值.
- 类动物的构造,特别是具有性芳香侧链的类动物,受到溶剂和链条长度等因素的影响,导致螺旋或螺纹循环结构.
- 了解形状控制是设计具有特定新型结构的体的关键.
研究的目的:
- 调查五芳香功能对类构造特征的影响.
- 为了合成和表征包含化构建块 (S) - 1 - 1 - - - - 乙烯胺的新型类物质.
- 探索pi-stacking和静电学在形折叠和形状偏好中的作用.
主要方法:
- 合成一种新的α-奇拉氨基基构建块, (S)-1-(pentafluorophenyl) 乙胺 (S-2).
- 使用S-2和非化类似物制备同型和异型类.
- 使用循环二元化 (CD) 和核磁共振 (NMR) 谱学的合成类的表征.
主要成果:
- 五甲基组没有显著增强异构类的pi堆叠相互作用.
- 纳入 (S) -N-(1-(pentafluorophenyl) ethyl) glycine单体诱导状结构在通常形成循环的peptoids.
- 一个单个 (S) -N-(1-(pentafluorophenyl) ethyl) glycine单体可以通过调整电子特性来选择性地控制循环或螺旋形状.
结论:
- 五芳香功能为操纵peptoid结构提供了一个新的策略.
- (S) -N-(1-(pentafluorophenyl) ethyl) glycine单体的战略位置提供了对类结构的精确控制.
- 这种方法使得能够构建具有量身定制的结构性质的新型结构.
相关概念视频
Protein Organization
Overview
Protein Folding
Overview
Protein and Protein Structure
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
Protein Folding
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Structure Is Critical to Its Biological Function
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RNA Structure
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...


