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Updated: Jul 13, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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一个功能性RNAi屏幕,用于受体氨酸激酶和ERK信号的调节者

Adam Friedman1, Norbert Perrimon

  • 1Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Nature
|November 7, 2006
PubMed
概括

这项研究使用了Drosophila的全基因组RNA干扰屏幕来识别细胞外信号调节激酶 (ERK) 信号的新型调节者. 屏幕显示了331个保存途径调节器,包括一种Ste20样酶和一种PPM家族酸酶,突出显示了潜在的药物标.

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