在心力衰竭和保存的喷射分数患者中,受损的慢性和血管扩张储备限制了运动能力
Barry A Borlaug1, Vojtech Melenovsky, Stuart D Russell
1Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
患有心力衰竭和保留射出分数 (HFpEF) 的患者由于慢性,血管扩张和心脏输出储备受损而表现出运动能力降低,而不仅仅是透支功能障碍.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 心脏衰竭研究研究
背景情况:
- 保存喷射分数 (HFpEF) 的心力衰竭影响了近一半的心力衰竭患者.
- 诸如运动不耐症之类的症状往往归因于透缩功能障碍.
- 在压力下减弱的缩或动脉血管扩张储备也可能有显著的贡献.
研究的目的:
- 与对照人群相比,研究HFpEF患者的运动心血管功能.
- 确定导致HFpEF运动能力下降的特定生理限制.
- 探索在HFpEF中改善运动耐受性的潜在治疗目标.
主要方法:
- 17名HFpEF患者和19名对照受试者接受了最大努力直立循环人体工程学.
- 放射性核素室内扫描用于评估休息和炼心血管功能.
- 研究对象因年龄,性别和常见的并发症如高血压和糖尿病而匹配.
主要成果:
- 与对照组相比,HFpEF患者表现出明显减少的运动持续时间和峰值氧气消耗.
- 在匹配的工作负载时,HFpEF患者表现出心率和心脏输出量大幅增加,血管扩张减少.
- 尽管HFpEF患者的末端透支体积和收缩率相似,但其慢性和血管扩张储备受损.
结论:
- 在运动期间,HFpEF患者表现出慢性,血管扩张和心脏输出储量的减少.
- 这些局限性不仅仅是由于透支异常.
- 这些发现表明,在HFpEF中增强运动能力的新型治疗目标.
更多相关视频
09:04Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
Published on: February 20, 2018
04:20Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
Published on: October 1, 2019
相关概念视频
Muscle Recovery and Fatigue
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Heart Failure VI: Adjunct Therapies
Heart Failure VII: Nursing Interventions
