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Updated: Jul 27, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

根据MHC I类分子进行类选择

T N Schumacher1, M L De Bruijn, L N Vernie

  • 1Department of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam.

Nature
|April 25, 1991
PubMed
概括

主体自身相容性复合体 (MHC) I 类分子优先结合短合成,特别是九种氨基酸. 这一发现解释了合成和自然加工的之间T细胞表皮质大小限制的差异.

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis09:32

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...