药房护理计划对药物坚持和持续性,血压和低密度脂蛋白胆固醇的影响:一项随机对照试验
Jeannie K Lee1, Karen A Grace, Allen J Taylor
1Department of Pharmacy, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.
JAMA
|November 15, 2006
概括
一个全面的药房护理计划显著改善了老年患者的药物坚持和持续性. 这导致了血压 (BP) 的显著降低,突显了该计划的有效性.
科学领域:
- 老年医学 老年医学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 药物坚持不良会对药物治疗结果产生负面影响.
- 患有冠状动脉风险因素的老年患者经常管理多种药物,增加不坚持的风险.
研究的目的:
- 评估综合药房护理计划在提高药物服药效率方面的有效性.
- 评估该计划对血压 (BP) 和低密度脂蛋白胆固醇 (LDL-C) 水平的影响.
主要方法:
- 一项多阶段前性研究,涉及200名老年患者 (≥65岁) 服用≥4种慢性药物.
- 干预阶段包括药物教育和药剂师随访,然后随机分配到继续药房护理或通常护理.
- 主要结局测量了药物坚持和持续性;次要结局包括BP和LDL-C的变化.
主要成果:
- 在6个月的干预后,药物坚持率从61.2%增加到96.9% (P<.001).
- 静脉血压和LDL-C在干预后显著改善.
- 与常规护理相比,在药房护理组观察到持续的坚持 (95.5%) 和显著的血压降低 (-6.9 mm Hg) (分别P<.001和P=.04).
结论:
- 药房护理计划有效地改善了老年患者的药物坚持和持续性.
- 该计划导致临床上显著的血压降低.
- 停止药房护理计划导致药物坚持和持续性降低.
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