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托尔特罗丁和坦苏洛辛用于治疗下尿路症状和膀过活的男性:一项随机对照试验.

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  • 1Department of Urology, Weill Cornell Medical College, New York, NY 10021, USA. kaplans@med.cornell.edu

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与托尔特罗丁延长释放 (ER) 和坦苏洛辛的联合治疗显著改善了膀过活的男性下尿路症状. 这种双重治疗为那些对单一治疗无反应的患者提供了安全有效的选择.

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 药理学 药理学是指药理学的学科.
  • 临床试验 临床试验

背景情况:

  • 患有过度活性膀 (OAB) 和下泌尿道症状 (LUTS) 的男性往往对单剂疗法,如抗肌糖类药物或α受体对抗剂,表现出有限的反应.
  • 良性前列腺增生症 (BPH) 经常与OAB共存,使治疗策略复杂化.

研究的目的:

  • 评估托尔特罗丁延长释放 (ER) 和坦苏洛辛的疗效和安全性,单独或组合使用,对被诊断患有OAB和BPH的男性.
  • 为男性患有耐火性LUTS确定最佳治疗方法.

主要方法:

  • 这是一项随机,双盲,安慰剂对照试验,涉及95家美国泌尿外科诊所.
  • 招聘标准包括40岁以上的男性,具有特定的国际前列腺症状评分 (IPSS) 和生活质量 (QOL) 评分,中度膀烦,以及记录的尿频和急性.
  • 参与者接受了安慰剂,托尔特罗丁ER (4毫克),塔姆苏洛辛 (0.4毫克) 或托尔特罗丁ER和塔姆苏洛辛的组合,持续了12周.

主要成果:

  • 接受组合治疗的80%的男性报告了治疗效益,明显高于安慰剂 (62%),单独的tamsulosin (71%) 或单独的tolterodine ER (65%).
  • 与安慰剂相比,组合组显示出急性尿失禁,没有失禁的急性发作和每天/每晚排尿的显著减少.
  • 组合治疗组的IPSS和QOL总得分也得到了改善.

结论:

  • 12周的托尔特罗丁ER加上坦苏洛辛的治疗对中度至重度LUTS的男性,包括OAB,显示出显著的益处.
  • 组合疗法耐受性良好,副作用的发生率很低,例如急性尿.
  • 这项研究支持使用组合疗法作为男性并发性OAB和BPH症状的有效治疗方法.