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Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...

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Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System
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需要较低的受体热情度用于胸膜克隆性缺失,而不是用于效应T细胞功能.

H Pircher1, U H Rohrer, D Moskophidis

  • 1Institute of Pathology, University Hospital, Zurich, Switzerland.

Nature
|June 6, 1991
PubMed
概括

胸腺中的克隆删除消除了自我反应的T细胞. 低度的相互作用足以进行胸膜缺失,仍然可以阻止外围T细胞的反应.

科学领域:

  • 免疫学 免疫学 免疫学
  • T细胞生物学T细胞生物学
  • 自我容忍是一种自我容忍.

背景情况:

  • 胸腺中的克隆缺失对于T细胞对自身抗原的耐受性至关重要.
  • 消极选择的精确机制,特异性和亲和/贪门仍然不完全理解.

研究的目的:

  • 为了研究T细胞受体 (TCR) 介导的负选择的精细特异性和亲和力/敏度值.
  • 阐明TCR相互作用强度和T细胞反应 (删除与激活) 之间的关系.

主要方法:

  • 使用过基因小鼠表达TCR特异性为淋巴细胞胆膜炎病毒 (LCMV) 糖蛋白/H-2Db.
  • 通过新生儿感染突变LCMVs改变T细胞表皮图的LCMV诱导的耐受性.
  • 评估了胸腺T细胞缺失和体内和体外抗病毒反应.

主要成果:

  • 使用突变的LCMVs实现了新生儿耐受性诱导.
  • 低度的TCR-抗原相互作用足以导致胸腺中的克隆缺失.
  • 这种相同的低贪度相互作用未能诱导外围的效应T细胞反应.

结论:

  • 胸腺中的负选择在相对于T细胞激活的更低的亲和度/贪度值下运行.

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  • 这种差异值允许消除潜在的自我反应性T细胞,同时保持对外来抗原的反应.
  • 对T细胞反应的微调是通过对胸膜删除和外周激活的明显的激情要求来实现的.