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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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通过Smyd2介导的甲基化抑制p53活性

Jing Huang1, Laura Perez-Burgos, Brandon J Placek

  • 1Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

Nature
|November 17, 2006
PubMed
概括

氨酸甲基化调节瘤抑制剂p53 (蛋白53). Smyd2在Lys 370中甲基化p53,抑制其功能,而Set9在Lys 372中的甲基化则抑制了这一作用. 减少Smyd2可以增强p53的作用.

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