一个控制释放的策略,用于生成交叉链接的水凝微结构
Giovanni Talei Franzesi1, Bin Ni, Yibo Ling
1Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Journal of the American Chemical Society
|November 23, 2006
概括
这项研究引入了一种创新的方法,用于制造精确形状的微尺度水凝. 这种技术克服了现有方法的局限性,使其在组织工程和药物输送方面具有先进的应用.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 药物运输 药物运输 药物运输
背景情况:
- 微型水凝对于细胞查,诊断,组织工程和药物输送等应用至关重要.
- 现有的微型成型技术受到许多水凝材料的快速交叉连接的限制.
- 对尺寸和形状定义的微水凝的控制制造对于先进的生物医学应用至关重要.
研究的目的:
- 开发一种新的制造微尺度水凝的新方法,以控制尺寸和形状.
- 为了克服传统微型成型技术中快速交联所带来的局限性.
- 为了证明这种方法在为组织工程和药物输送创建复杂的微型架构时的实用性.
主要方法:
- 从水凝模具中通过受控的凝剂释放制造微型酸盐和酸盐结构.
- 采用复制成型用于图案膜和微转移成型用于形状控制的微粒.
- 生成带有细胞的3D微凝和复合液凝,具有空间分离的区域.
主要成果:
- 成功制造大小和形状受控制的3D微凝,包括带有细胞的结构.
- 创建的复合水凝具有明确的,空间分离的区域.
- 经过形状控制的微观结构的证明,能够分别释放负载的宏分子.
结论:
- 开发的方法可以制造复杂的微观水凝结构,精确控制尺寸和形状.
- 这种技术可用于生产用于组织工程应用的先进微型架构.
- 该方法显示,由于控制释放特性,药物输送应用具有显著的潜力.
相关概念视频
01:01Phosphodiester Linkages
Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
00:49Ligand Binding and Linkage
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
02:04Covalently Linked Protein Regulators
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
These groups modify specific amino acids in a protein.