肠红细胞疟疾寄生虫直接进入血清大分子
B Pouvelle1, R Spiegel, L Hsiao
1Department of Pathology and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107.
Nature
|September 5, 1991
概括
红细胞中的疟疾寄生虫利用独特的寄生虫导管吸收营养,绕过传统的膜穿越. 这一发现表明寄生虫表面抗原具有新的治疗点.
科学领域:
- 细胞生物学 细胞生物学
- 寄生虫学的寄生虫学
- 免疫学 免疫学 免疫学
背景情况:
- 疟疾寄生虫Plasmodium falciparum居住在红细胞内,由宿主和寄生虫膜分开.
- 了解跨越这些壁垒的营养物质运输对于开发抗疟疾战略至关重要.
研究的目的:
- 阐明巨分子进入红细胞内的疟疾寄生虫的机制.
- 为了确定抗体介导治疗疟疾的潜在目标.
主要方法:
- 寄生虫细胞真空膜和红细胞膜之间的膜连续性的可视化.
- 在受阻内细胞形成条件下,用光宏分子对寄生虫的表面进行标记.
主要成果:
- 大分子不会穿过红细胞或寄生虫的真空膜.
- 一个寄生虫通道提供了直接进入围绕寄生虫的水空间.
- 寄生虫通过液相内细胞分解从周围的体内化大分子.
结论:
- 寄生虫导管是内红细胞疟疾寄生虫获取营养的关键结构.
- 巨虫和虫的表面抗原是针对抗体导向的寄生虫杀伤剂的可行的点.
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