在OPV染色体中进行状对齐:利用基于ureaidophthalimide的折叠分子
Renatus W Sinkeldam1, Freek J M Hoeben, Maarten J Pouderoijen
1Contribution from the Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Journal of the American Chemical Society
|December 15, 2006
概括
这项研究表明,溶剂选择如何影响装饰着oligo(p-phenylenevinylene) (OPV) 染色体的poly(ureidophthalimide) 折叠体的超分子性. 这些发现突出了折叠机自组装中依赖溶剂的二次结构表达.
科学领域:
- 超分子化学 超分子化学
- 聚合物科学 聚合物科学
- 有机化学 有机化学
背景情况:
- 折叠分子是合成聚合物,模仿自然生物分子的二次结构.
- 聚 ((ureaidophthalimide) 折叠体作为组织功能组的支架.
- 奥利戈 (p-phenylenevinylene) (OPV) 染色体因其光学特性而被利用.
研究的目的:
- 为了研究OPV染色体在聚胺胺胺基折叠体支架上的奇拉组织.
- 探索溶剂对这些折叠分子的二级结构和超分子性的影响.
- 描述折叠体-染色体结合体的自我组装行为.
主要方法:
- 用OPV装饰的折叠模块构建块的合成和随后的聚合.
- 用染色学分离聚合物链.
- 循环二重化 (CD) 光谱法用于研究二次结构和性.
- 扫描道显微镜 (STM) 用于可视化自组装架构.
主要成果:
- 有几个转的螺旋结构是使用较长的折叠机链建造的.
- 循环二元化研究揭示了OPV的溶剂依赖螺旋布局 (观察到THF,而不是CHCl3).
- 一个双标的Cotton效应在heptane中表明了超分子性表达,这取决于溶剂史 (THF与CHCl3).
- STM分析显示,在石墨/1-烯酸接口上由较短的寡合体形成的圆形结构.
结论:
- 溶剂在决定折叠分子的二级结构中的超分子性表达方面发挥着关键作用.
- 折叠体支架有效地组织了OPV染色体,从而产生了对溶剂有反应的性组件.
- 观察到的自组装行为与装饰的折叠板的拟议折叠构造一致.
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