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Updated: Jul 16, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
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An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

对ddI的耐药性和对AZT的敏感性是由HIV-1逆转录酶突变引起的

M H St Clair1, J L Martin, G Tudor-Williams

  • 1Division of Virology, Burroughs Wellcome Co., Research Triangle Park, NC 27709.

Science (New York, N.Y.)
|September 27, 1991
PubMed
概括

将HIV-1治疗从齐多夫丁 (AZT) 转换为迪达诺辛 (ddI) 导致ddI敏感性降低,而AZT敏感性增加. 一个特定的突变出现了,赋予了对ddI的耐药性,并抑制了对AZT的耐药性,突出显示了组合疗法的重要性.

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