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Updated: Jul 18, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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由酵母内核酶产生的DNA断裂介导的抗体类切换

Ali A Zarrin1, Catherine Del Vecchio, Eva Tseng

  • 1Howard Hughes Medical Institute, Children's Hospital, CBR Institute for Biomedical Research, and Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 16, 2006
PubMed
概括

抗体类别切换 (CSR) 可以发生在没有切换 (S) 区域或激活诱导的cytidine deaminase (AID) 的情况下. 特定站点的DNA双链断裂 (DSB) 可以驱动CSR,这表明CSR是从一般的DNA修复机制进化而来的.

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