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Updated: Jul 18, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

GlcNAcstatin:一种皮科莫尔,选择性的O-GlcNAcase抑制剂,可以调节细胞内O-glcNAcylation水平

Helge C Dorfmueller1, Vladimir S Borodkin, Marianne Schimpl

  • 1Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

Journal of the American Chemical Society
|December 21, 2006
PubMed
概括

研究人员开发了GlcNAcstatin,这是O-GlcNAcase酶的高度选择性抑制剂. 这种新化合物有效地提高了O-GlcNAc水平,为研究细胞信号通路提供了强大的工具.

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