不对称细胞分裂的终止和胃体的分化
Lynn Jo Pillitteri1, Daniel B Sloan, Naomi L Bogenschutz
1Department of Biology, University of Washington, Seattle, Washington 98195, USA.
Nature
|December 22, 2006
概括
阿拉比多普西斯莉亚的基本螺旋环-螺旋环 (bHLH) 蛋白 MUTE 在植物口腔发育中起着至关重要的作用. 它控制了美里斯类细胞转化为专门的护卫细胞,这对于气体交换至关重要.
科学领域:
- 植物生物学 植物生物学
- 发育生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 胃体由守护细胞组成,调节植物中的气体和水的交换.
- 胃前体细胞 (meristemoids) 具有干细胞特性,在分化之前不对称地分裂.
研究的目的:
- 为了确定控制美里斯形命运过渡和随后的口腔分化在Arabidopsis thaliana的关键调节者.
- 阐明MUTE及其对应物在口腔发育的连续步骤中的作用.
主要方法:
- 对缺乏MUTE功能的Arabidopsis thaliana突变物进行遗传分析.
- 过度表达研究,以评估MUTE对表皮细胞命运的影响.
- 对MUTE及其同类SPEECHLESS (SPCH) 和FAMA进行比较分析.
主要成果:
- 失去MUTE功能会导致细胞循环停止并导致牙分化的失败.
- MUTE过度表达导致整个表皮采用护卫细胞的身份.
- 通过指导第一个不对称的分裂,SPCH启动了口腔系,MUTE介导了美里斯泰分化,FAMA调节了护卫细胞形态发生.
结论:
- MUTE是一个关键的开关,用于meristemoid分化到胃.
- bHLH蛋白质SPCH,MUTE和FAMA连续作用,以控制植物口腔发育.
- 这些发现证明了相关的bHLH蛋白在跨王国细胞分化中的保留作用.
更多相关视频
10:56Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
Published on: May 5, 2022
25.4K
08:45Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach
Published on: January 26, 2024
2.1K
相关概念视频
Adult Stem Cells
27.8K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
27.8K
Distribution of Cytoplasmic Content
3.3K
Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
3.3K
Renewal of Intestinal Stem Cells
2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K
Tissue Renewal without Stem Cells
1.6K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
1.6K
Cellular Differentiation
5.7K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
5.7K
Mucosal Barrier of the Stomach
2.6K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.6K
