声波刺在德里希提亚中的功能和附属物图案的演变
Randall D Dahn1, Marcus C Davis, William N Pappano
1Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA.
Nature
|December 26, 2006
概括
声波刺 (Shh) 基因调节在脊椎动物配对附属体进化中得到了深度保护. 孔德里希提亚人与光鱼和四足动物共享Shh表达和功能模式,揭示了保存的遗传机制.
科学领域:
- 进化发育生物学 进化发育生物学
- 进行比较的基因组学.
- 脊椎动物的古生物学
背景情况:
- 已知四足动物四肢发育的遗传学,但进化组合和基底脊椎动物的功能仍然不清楚.
- 孔德里希提亚人,原始的脊椎动物配对的附属物,被认为有Sonic hedgehog (Shh) 独立的附属物骨架图案.
- 这与光鱼和四足动物形成了鲜明对比,表明它们的进化路径有所不同.
研究的目的:
- 研究基底脊椎动物中Sonic hedgehog (Shh) 基因功能的进化保护.
- 为了澄清Shh在德里希附属体发育中的作用及其进化含义.
- 为了比较主要脊椎动物血统的SHH调节.
主要方法:
- 在chondrichthyans中对Shh基因表达模式的比较分析.
- 识别和表征SHH附属体特定的调节性DNA元素.
- 功能性研究评估Shh在尾模式中的作用.
主要成果:
- 孔德里希蒂亚人表现出保存的附属物Shh表达的模式.
- 类似的Shh附属体特定的调节DNA序列在chondrichthyans,光鱼和四足动物中被确定.
- 有证据表明,Shh在德里希特人附属体的图案中起着保留的功能作用.
结论:
- 声波刺 (Shh) 在尾发育中的功能在脊椎动物的基因组中得到了深度保护.
- Shh调节机制的进化可能导致了附属物进化过程中的重大形态变化.
- 孔德里希提亚人与其他脊椎动物共享基本的Shh-依赖的模式机制.
相关概念视频
Hair Cells
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Characteristics of OpAmp
The operational amplifier, commonly known as an op-amp, is a specially designed electronic circuit component. Its purpose is to work in conjunction with other circuit elements to execute a defined signal-processing operation. Consider an equivalent circuit model of an op-amp, as depicted in Figure 1; the output section comprises a voltage-controlled source in parallel with the output resistance Ro.
Characteristics of Practical Op Amps
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
Instrumentation Amplifier
An electrocardiography (ECG) machine is an essential piece of medical equipment used to monitor the electrical activity of the heart. It operates by detecting small electrical changes on the skin that result from the depolarization of the heart muscle during each heartbeat. However, these signals are in the microvolt range and can be easily overwhelmed by noise or interference.
To overcome this challenge, an ECG machine utilizes an instrumentation amplifier. This specialized amplifier is...
To overcome this challenge, an ECG machine utilizes an instrumentation amplifier. This specialized amplifier is...
Design Example
The innovation of touch-tone telephony revolutionized the telecommunications industry by replacing the traditional rotary dial with a dual-tone multi-frequency (DTMF) signaling system. This system uses a matrix-style keypad with buttons arranged in four rows and three columns, creating 12 distinct signals each assigned to a pair of frequencies. Each button press results in a simultaneous generation of two sinusoidal tones – one from a low-frequency group (697 to 941 Hz) and one from a...


