降低ES电池中的噪音.
1Baylor College of Medicine, Department of Molecular and Cellular Biology and Center for Cell and Gene Therapy, One Baylor Plaza, Houston, TX 77030, USA. tpzwaka@bcm.edu
Cell
|December 28, 2006
概括
胚胎干细胞使用蛋白质体来防止不必要的基因激活,确保它们在需要时准备分化. 这种蛋白质酶介导的控制维持了它们的发育潜力.
科学领域:
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 胚胎干细胞 (ES) 具有独特的能力,可以分化为各种细胞类型.
- 维持多能性需要精确调节基因表达,以防止过早的分化.
- 转录噪声可能导致不适当的基因激活和干细胞身份的丧失.
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