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相关概念视频

Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Fractures: Bone Repair01:27

Fractures: Bone Repair

5.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K
Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K

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相关实验视频

Updated: May 5, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

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治疗5年后继续或停止使用阿伦德罗纳特的效果:骨折干预试验长期延长 (FLEX):一个随机试验.

Dennis M Black1, Ann V Schwartz, Kristine E Ensrud

  • 1San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA. dblack@psg.ucsf.edu

JAMA
|December 28, 2006
PubMed
概括
此摘要是机器生成的。

在绝经后的骨质疏松症中5年后停止服用阿伦德罗纳酸对大多数女性来说是安全的,没有显示骨折风险增加. 然而,有高脊椎骨折风险的女性可能会受益于持续治疗超过5年.

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An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
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An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

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Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
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Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

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相关实验视频

Last Updated: May 5, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

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An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

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Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

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科学领域:

  • 内分泌学 在内分泌学.
  • 老年病的医生 老年病的医生
  • 类风湿病学 类风湿病学

背景情况:

  • 绝经后骨质疏松症的最佳治疗持续时间仍然不确定.
  • 阿伦德罗纳酸是骨质疏松症的常见治疗方法.

研究的目的:

  • 在患有骨质疏松症的绝经后妇女中,比较5年后停止阿伦德罗纳特治疗的效果与持续10年的效果.

主要方法:

  • 一个随机的双盲试验,涉及1099名以前接受过阿伦德罗纳特治疗的绝经后妇女.
  • 参与者被随机分配,继续服用阿伦德罗纳特 (5或10毫克/天) 或转换为安慰剂5年.
  • 主要结局是部总骨矿物密度 (BMD);次要结局包括其他部位的BMD,骨周转标志物和骨折发生率.

主要成果:

  • 停止服用阿伦德罗纳特导致骨硬度的适度下降,但水平仍然高于之前的值.
  • 停药后骨周转指标增加,但仍低于初始水平.
  • 两组之间没有观察到非脊椎骨折风险的显著差异.
  • 持续使用阿伦德罗纳特显著降低了临床认可的脊椎骨折的风险.

结论:

  • 在5年后停止服用阿伦德罗纳特与中度的骨髓质量损失和骨周转率标记物的增加有关,但不会显著增加整体骨折风险.
  • 对于大多数女性来说,5年的阿伦德罗纳特治疗疗程似乎足够.
  • 临床脊椎骨折风险较高的女性可能会从延长的阿伦德罗纳特治疗中受益,超过5年.