专利卵孔和高海拔肺
Yves Allemann1, Damian Hutter, Ernst Lipp
1Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Inselspital, Bern, Switzerland. yves.allemann@insel.ch
JAMA
|December 28, 2006
概括
在易患高海拔肺水腫 (HAPE) 的人群中, patent foramen ovale (PFO) 是四倍更常见的. 大量的PFO与高海拔地区更严重的低氧化症有关,可能有助于HAPE的发展.
科学领域:
- 心脏病学 心脏病学
- 高度医学 高度医学
- 肺部医学 肺部医学
背景情况:
- 高海拔肺 (HAPE) 涉及过度的肺高血压和低氧化,其机制尚不清楚.
- 卵孔 (PFO) 经过述,与HAPE的低氧化症恶化有关.
研究的目的:
- 为了调查PFO在HAPE易感个体中更普遍的假设.
- 为了确定PFO是否会在高海拔地区导致更严重的动脉低氧症.
主要方法:
- 一项病例控制研究比较了16名HAPE易感个体和19名HAPE耐药的登山者.
- 经食道心声学确定了PFO,多普勒心声学估计了肺动脉压力,脉冲氧度测量了低高度和高高度的动脉氧和度.
主要成果:
- 在HAPE易感个体中,PFO的频率是HAPE易感个体的四倍以上 (56%对11%在低海拔地区;69%对16%在高海拔地区).
- 对HAPE敏感的个体在高海拔地区表现出明显较低的动脉氧和度 (73%对83%).
- 在HAPE易感组中,那些PFO大的人患有更严重的低氧症 (65%vs77%).
结论:
- 在易受HAPE感染的个体中, patent foramen ovale明显更常见.
- 在高海拔地区的大型PFO与更严重的低氧血症有关.
- 在高海拔地区,PFO可能是导致过度低氧化和HAPE发展的因素.
相关概念视频
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