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瘤坏死因子-α诱导Lepr(db) 小鼠内皮功能障碍

Xue Gao1, Souad Belmadani, Andrea Picchi

  • 1Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.

Circulation
|January 4, 2007
PubMed
概括

瘤坏死因子-α (TNF) 通过增加氧化应激来驱动2型糖尿病中的内皮功能障碍. 阻止TNF或其下游效应恢复了糖尿病小鼠的血管功能.

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Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...