心肌缺血记忆成像与分子心声回声学
Flordeliza S Villanueva1, Erxiong Lu, Shivani Bowry
1Cardiovascular Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. villanuevafs@msx.upmc.edu
Circulation
|January 11, 2007
概括
针对精选素的新型超声波对比剂可以识别最近缺血性心肌. 这一突破可能使得胸痛患者的急性冠状动脉综合征的早期和更准确的诊断成为可能.
科学领域:
- 心血管成像 - 心血管成像
- 生物材料科学 生物材料科学
- 诊断医学 诊断医学
背景情况:
- 诊断急性冠状动脉综合征 (ACS) 存在挑战,因为难以识别心肌缺血.
- 白细胞粘附分子在缺血/再输液期间在内皮上升调,在缺血事件发生后持续存在.
研究的目的:
- 开发针对内皮选择蛋白的微泡,用于对最近缺血性心肌的心声学鉴定.
- 评估这些向微气泡在心肌缺血的老鼠模型中的有效性.
主要方法:
- 合成的脂质微泡与sialyl Lewis ((x)) (MB ((sLex)) 和控制微泡 (MB ((CTL)) 结合在一起.
- 在小鼠中使用静脉内显微镜评估微气泡对炎症内皮的附着性.
- 在冠状动脉封闭和再输后,在老鼠身上进行了心声成像,注射了MB(sLex) 或MB(CTL).
主要成果:
- MB(sLex) 与对照气泡相比,对炎症的内皮具有显著更强的粘附性.
- 心声检查显示,使用MB(sLex) 与MB(CTL) 相比,在后血性心肌中化程度更大.
- 免疫染证实了在缺血性心肌中P-选择素的表达.
结论:
- 最近缺血性心肌的心声识别可以通过选择向的超声波对比剂来实现.
- 这种方法有望为急性冠状动脉综合征的早期和更精确的诊断提供希望.
- 为患有心脏来源不明的胸痛的患者提供了潜在的新诊断工具.
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