人类免疫缺陷病毒遗传变异,可以逃避细胞毒性T细胞识别
R E Phillips1, S Rowland-Jones, D F Nixon
1Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK.
Nature
|December 12, 1991
概括
抗击艾滋病毒的细胞毒性T细胞的有效性波动. 患者的病毒突变使艾滋病毒能够逃避这些免疫细胞,这是免疫逃脱的关键机制.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 细胞毒性T淋巴细胞 (CTLs) 对于控制病毒感染至关重要,包括人类免疫缺陷病毒 (HIV).
- 艾滋病毒表现出显著的遗传多样性,这可能会影响其被宿主免疫系统识别.
研究的目的:
- 研究CTL特异性与HIV阳性个体随时间推移的病毒遗传变异之间的动态关系.
- 为了确定病毒表位序列的变化是否与改变的CTL反应相关,并有助于免疫逃脱.
主要方法:
- 对艾滋病病毒阳性患者的纵向分析.
- 对抗HIV的细胞毒性T细胞特异性的评估.
- 在患者的淋巴细胞中测序Proviral gag DNA表位.
主要成果:
- 观察到针对HIV的细胞毒性T细胞的特异性波动.
- 在同一患者的淋巴细胞内检测到proviral gag DNA表位序列的变异性.
- 确定了特定的病毒变异,这些变异无法被患者的T细胞识别.
结论:
- 针对T细胞表位的病毒基因突变存在于HIV感染个体中.
- 这些突变的积累提供了HIV免疫逃脱的机制.
- 了解这种动态相互作用对于开发有效的HIV免疫疗法至关重要.
相关概念视频
Cell-mediated Immune Responses
Overview
Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Diversity of Antigen Receptors
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...


