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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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乌比基因化调节PTEN核进口和瘤抑制

Lloyd C Trotman1, Xinjiang Wang, Andrea Alimonti

  • 1Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Cell
|January 16, 2007
PubMed
概括

核PTEN对于瘤抑制至关重要,其进口通过单双化介导. 与癌症相关的PTEN突变破坏了这一过程,通过影响蛋白质稳定性,影响瘤进展.

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