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Updated: Jun 19, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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Published on: August 13, 2013

由于减弱的Foxp3表达,调节性T细胞功能被颠覆和转化

Yisong Y Wan1, Richard A Flavell

  • 1Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA.

Nature
|January 16, 2007
PubMed
概括

调控性T细胞 (T(r)) 控制自我耐受性,而Foxp3对它们的功能至关重要. 这项研究表明,减少Foxp3表达会损害T(r) 细胞抑制,通过将它们转化为效应细胞,导致自身免疫性疾病.

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