多模式分子成像识别了早期大动脉病的蛋白质和骨质活动
Elena Aikawa1, Matthias Nahrendorf, David Sosnovik
1Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA. eaikawa@partners.org
Circulation
|January 17, 2007
概括
分子成像检测早期的大动脉病通过可视化细胞变化,如炎症和骨质生成 in vivo. 这种方法有助于预测风险,并确定预防大动脉狭窄的治疗目标.
科学领域:
- 心血管研究研究心血管研究
- 医疗成像医学成像
- 翻译医学是一种翻译医学.
背景情况:
- 早期发现大动脉狭窄症 (AVS) 对于风险预测和治疗干预至关重要.
- 了解AVS的发病因子,特别是它与动脉样硬化的相似性,是关键.
- 需要对膜细胞功能变化的体内可视化.
研究的目的:
- 测试一下大动脉狭窄是否与动脉样硬化有着共同的病原性.
- 评估分子成像在体内早期检测大动脉膜疾病变化的能力.
- 在早期AVS中使用先进的成像剂绘制细胞事件的地图.
主要方法:
- 使用近红外光成像剂在高胆固醇贫血的阿波利波蛋白E缺陷小鼠中.
- 在大动脉中绘制了内皮细胞,巨细胞,蛋白质溶解和骨质生成.
- 采用MRI和向纳米颗粒用于增强成像和细胞活动检测.
主要成果:
- 缺陷的大动脉的小鼠表现出增加的厚度,巨细胞的存在和早期功能障碍.
- 针对巨细胞的纳米颗粒检测到巨细胞在患病的门中吸收巨细胞.
- 蛋白质分解活性和骨质生成在炎症的门中可视化,在化之前.
结论:
- 分子成像可以有效地检测早期大动脉膜疾病中的关键体内细胞事件.
- 确定了内皮细胞激活,巨细胞活动,蛋白质分解和骨质生成.
- 这种成像方法对AVS风险分层和治疗标识有前途.
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