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Updated: Jul 14, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

索兰德莱克E的酶选择性合成和结构修订

Jennifer E Davoren1, Stephen F Martin

  • 1Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.

Journal of the American Chemical Society
|January 18, 2007
PubMed
概括

No abstract available in PubMed .

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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...