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分子纳米的设计和优化基于可回氧切换的可双相稳定罗塔克桑
Thoi D Nguyen1, Yi Liu, Sourav Saha
1California NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095-1569, USA.
Journal of the American Chemical Society
|January 18, 2007
概括
研究人员开发了可氧化还原控制的分子纳米,使用半孔纳米颗粒和可可视化[2]rotaxanes. 纳米效率取决于守门员的位置和链接器的长度,以控制发光探针的释放.
科学领域:
- 超分子化学 超分子化学
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 半孔纳米粒子 (MSN) 是用于药物输送和传感的多功能平台.
- 分子开关对于开发响应性纳米材料至关重要.
- 双可塑性 [2] 罗塔克桑为纳米级应用提供可控制的机械运动.
研究的目的:
- 使用MSN和可二氧化 [2]rotaxanes制造可回氧控制的分子纳米.
- 为了研究守门员位置 (IN/OUT) 和链接器长度对纳米性能的影响.
- 为了证明光发分子的受控加载和释放.
主要方法:
- 用不同长度的连接器将可二元化 [2] 罗塔克桑与二氧化基质进行共价附着.
- 纳米的分类基于罗塔守门员的位置 (IN或OUT).
- 使用氧化还原刺激 (亚酸) 刺激纳米的打开/关闭,并通过发光监测探针释放.
主要成果:
- 纳米带着门卫在毛孔 (IN) 内更深,显示出比靠近孔隙 (OUT) 的纳米更高的效率.
- 在表面和罗塔克桑之间较短的连接器导致了较少的泄漏纳米.
- 实现了可控加载和按需释放的发光探针 (,复合物,罗达胺B).
结论:
- 基于MSN和可二氧化 [2]rotaxanes的可逆氧控制纳米是可行的和高效的.
- 守门员的定位和链接器的长度是优化纳米性能和最大限度地减少泄漏的关键参数.
- 这些纳米为各种领域的控制释放应用提供了一个有前途的平台.
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