超分子PEG-co-oligo (p-胺) 在合成器上制备
Hannah M König1, Tatiana Gorelik, Ute Kolb
1Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.
Journal of the American Chemical Society
|January 18, 2007
概括
通过在固体支上使用Fmoc化学,实现了基胺的自动合成. 由此产生的区块同类聚合物表现出聚合,并在各种溶剂中形成刚性棒状结构.
科学领域:
- 聚合物化学 聚合物化学
- 有机合成 有机合成
- 材料科学 材料科学 材料科学
背景情况:
- 奥利戈化物 (Oligo ((p-benzamide)) 是一种硬棒聚合物的类别,在先进材料中具有潜在的应用.
- 固体相合成为控制的寡合化和净化提供了优势.
研究的目的:
- 开发一个自动化固体相合成协议的oligo (p-胺) s.
- 为了研究合成的区块共聚体的自我组装和构造行为.
主要方法:
- 使用商用合成器,修改了Fmoc化学,用于自动合成.
- 使用 bis ((三甲基碳酸盐) 激活芳香碳酸.
- 合成了N-受保护的hepta (p-胺) 并附上了一个聚乙烯糖醇 (PEG) 链.
主要成果:
- 在固体支上成功制备了N-保护的hepta (p-benzamide).
- 在保护组的最小损失的情况下,实现了从支部裂开.
- 证明了不受保护的区块同类聚合物表现出强烈的聚合,并在溶液 (,,水) 中形成刚性棒状结构.
结论:
- 已经建立了一个高效的自动化固体相合成路径,用于化.
- 合成的区块共聚物体具有独特的自我组装特性,在各种溶剂中形成有序聚合物.
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