在1918年流感病毒致命感染的异常天生的免疫反应
Darwyn Kobasa1, Steven M Jones, Kyoko Shinya
1Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.
Nature
|January 19, 2007
概括
1918年流感病毒在中引起严重的呼吸系统疾病和死亡. 这些灵长类动物的非典型免疫反应导致了致命的结果,这表明病毒性流感病毒之间有一个共同的特征.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 1918年流感大流行导致全球数百万人死亡.
- 1918年流感病毒在小鼠中具有高度致病性,具有多基因源的毒性.
- 它在灵长类动物中的病原性潜力仍然没有被描述.
研究的目的:
- 在灵长类动物模型中研究1918年流感病毒的致病性.
- 了解灵长类动物对1918年流感病毒感染的宿主免疫反应.
主要方法:
- 1918年流感病毒感染了Cynomolgus的感染.
- 感染动物的临床观察和病理评估.
- 分析宿主免疫反应,包括抗病毒反应.
主要成果:
- 1918年的流感病毒在中引起了严重的,致命的呼吸道感染.
- 受感染的子表现出急性呼吸困难.
- 主体免疫反应失调,不足以保护,这表明非典型的先天免疫力.
结论:
- 1918年流感病毒在灵长类动物中具有高度致病性,导致致命的呼吸道疾病.
- 失调的先天免疫反应可能会导致病毒性流感感染的致命性.
- 调节宿主免疫反应是毒性流感病毒潜在的共同特征.
更多相关视频
07:36Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
2.6K
09:37Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
1.8K
相关概念视频
Viral Recombination
22.3K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
22.3K
Cell-mediated Immune Responses
64.7K
Overview
64.7K
Humoral Immune Responses
66.2K
Overview
66.2K
Vaccinations
44.1K
Overview
44.1K
Immune Response Against Viral Pathogens
2.4K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.4K
Immunodeficiency Diseases
3.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
3.7K
