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Updated: Jul 16, 2026

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue
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Published on: April 27, 2012

在发育和成熟的调节性T细胞中对Foxp3点基因进行全基因组分析

Ye Zheng1, Steven Z Josefowicz, Arnold Kas

  • 1Department of Immunology, University of Washington, Seattle, Washington 98195, USA.

Nature
|January 24, 2007
PubMed
概括

转录因子Foxp3控制了调节性T (Treg) 细胞的发育. 这项研究确定了Foxp3的点,揭示了其在基因激活/抑制中的双重作用,以建立Treg细胞功能.

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Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...