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通过Runx2对rRNA基因的线粒体占用和谱系特定的转录控制

Daniel W Young1, Mohammad Q Hassan, Jitesh Pratap

  • 1Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

Nature
|January 26, 2007
PubMed
概括

哺乳动物Runx2通过RNA聚合酶I (Pol I) 抑制核糖体RNA (rRNA) 合成,将细胞命运与细胞生长联系起来. 缺乏Runx2可以增强rRNA转录和蛋白质合成.

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