作为转录节点和治疗点的氧体增殖器激活受体
Jonathan D Brown1, Jorge Plutzky
1Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass, USA.
Circulation
|January 31, 2007
概括
过氧体增殖器激活受体 (PPARs) 调节新陈代谢和炎症. 虽然PPAR激动剂对心血管疾病具有治疗效果,但临床试验结果不一致,因此需要对PPAR生物学进行进一步研究.
科学领域:
- 分子生物学分子生物学
- 代谢研究研究 代谢研究
- 心血管科学 心血管科学
背景情况:
- 过氧体增殖器激活受体 (PPAR) 是调节脂质代谢,脂肪生成和胰岛素敏感性的核受体.
- 这三种PPAR同型 (α,gamma,delta) 都与炎症和动脉样硬化途径有关.
- PPARs通过控制多个基因标来整合代谢和血管功能.
研究的目的:
- 审查PPARs在代谢和血管路径中的作用.
- 评估PPAR作为心血管疾病的治疗点.
- 分析现有的临床试验数据,指导未来的PPAR调节器开发.
主要方法:
- 对体外,动物模型和人体代孕标志物研究的审查.
- 从PPAR激动剂研究中分析临床试验数据.
- 检查PPAR功能背后的生物机制.
主要成果:
- PPAR已被确立为药物点,纤维化物 (PPAR-alpha) 和 thiazolidinediones (PPAR-gamma) 在临床使用中.
- 有证据表明,PPAR激活可以减少炎症和动脉样硬化.
- 使用PPAR激动剂的初始大规模心血管试验产生了不同的结果.
结论:
- PPARs代表了关键节点,整合了能量平衡和血管健康.
- 尽管临床试验结果各不相同,但PPAR仍然是有前途的治疗点.
- 对PPAR生物学的更深入的理解对于推进基于PPAR的治疗方法至关重要.
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