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相关概念视频

Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Fluid Mosaic Model01:19

Fluid Mosaic Model

Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
Viscosity01:17

Viscosity

When water is poured into a glass, it falls freely and quickly, whereas if honey or maple syrup is poured over a pancake, it flows slowly and sticks to the surface of the container. This difference in the flow of different kinds of liquids arises due to the fluid friction between the liquid layers and the liquid and the surrounding material. This property of fluids is called fluid viscosity. In this example, water has a lower viscosity than honey and maple syrup.
The SI unit of viscosity is...
Couette Flow01:22

Couette Flow

Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...

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相关实验视频

Updated: Jun 30, 2026

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
07:18

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers

Published on: January 16, 2019

在混合双层膜中的脂质层流动性的表征和控制.

Neil A Anderson1, Lee J Richter, John C Stephenson

  • 1Department of Physics, National Institute of Standards and Technology, 100 Bureau Drive MS8443, Gaithersburg, Maryland 20899-8443, USA.

Journal of the American Chemical Society
|February 1, 2007
PubMed
概括
此摘要是机器生成的。

混合双层膜的凝到液晶相转变温度可以通过底层自组装单层来控制. 这一发现为高级应用程序调整脂质膜特性提供了洞察力.

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Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
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Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces
08:05

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

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科学领域:

  • 材料科学 材料科学 材料科学
  • 生物物理学的生物物理.
  • 表面化学 表面化学

背景情况:

  • 混合双层膜 (HBM) 是研究脂质膜行为的模型系统.
  • 凝到液晶 (LC) 阶段过渡温度,T(m),是脂质双层的一个关键性质.
  • 之前的研究表明,T(m) 受HBM自组装单层 (SAM) 底层的影响.

研究的目的:

  • 为了研究SAM底层对HBMs远端脂质层的T (m) 的影响.
  • 通过SAM修改建立对HBM脂质层T (m) 的控制.
  • 探索SAM组成/包装和脂质上层T ((m) 之间的关系.

主要方法:

  • 使用振动总频谱学 (VSFS) 对于其对脂酸链顺序/乱的敏感性.
  • 系统地改变了SAM底层的组成 (alkane thiol, thiolipid,混合SAM).
  • 在不同的SAM上测量了酸丁胆脂覆盖层的T (m).

主要成果:

  • 证明HBMs中的脂质层T(m) 对SAM底层敏感.
  • 观察到,通过选择SAM成分和/或包装密度,可以有效控制T{\displaystyle T}m.
  • 量化了不同SAM对脂质覆盖层相变行为的影响.

结论:

  • 底层SAM的组成和包装密度显著影响HBM的相位过渡温度.
  • 这为调整混合双层膜的特性提供了一种方法.
  • 这些发现对于设计功能化表面和理解膜生物物理学至关重要.