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Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
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Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

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通过针对其NADPH位点的纳米触发器对内皮NO合成酶活性进行同步光启动

Edward Beaumont1, Jean-Christophe Lambry, Clément Gautier

  • 1Unité 696, INSERM, Palaiseau France.

Journal of the American Chemical Society
|February 1, 2007
PubMed
概括

研究人员开发了一种新的纳米触发器,精确地准NADPH结合部位,以控制酶活性. 这种纳米触发器使光诱导的电子转移成为可能,从而启动酶反应,并为生物化学研究提供了一个新的工具.

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相关概念视频

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...