在非ST升高急性冠状动脉综合征患者中,生长差异化因子-15的预后值
Kai C Wollert1, Tibor Kempf, Timo Peter
1Department of Cardiology and Angiology, Hannover Medical School, Germany. wollert.kai@mh-hannover.de
Circulation
|February 7, 2007
概括
增长差异化因子-15 (GDF-15) 是一种用于预测非ST升高急性冠状动脉综合征患者死亡风险的新型生物标志物. 较高的GDF-15水平可独立识别一个年内死亡风险较高的个体.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 急性冠状动脉综合征是什么
背景情况:
- 增长分化因子-15 (GDF-15) 是一种细胞因子,在缺血-再输血损伤后在心脏中诱导.
- 升高的GDF-15水平可能在非ST升高急性冠状动脉综合征 (NSTE-ACS) 中具有预后价值.
研究的目的:
- 调查GDF-15在NSTE-ACS患者的预后价值.
- 为了确定GDF-15是否提供了超出既定标记的额外风险信息.
主要方法:
- 来自2081名NSTE-ACS患者和429名健康对照者的血液样本使用免疫放射测定分析了GDF-15水平.
- 进行了考克斯回归和接收器运行特征 (ROC) 曲线分析,以评估死亡风险.
主要成果:
- 三分之二的NSTE-ACS患者的GDF-15水平高于正常水平,其中三分之一的GDF-15水平超过1800 ng/L.
- 增加GDF-15三角形与增加1年死亡风险相关 (1.5%至14.1%,P<0.001).
- GDF-15是1年死亡率的独立预测指标 (AUC=0.757,截止值=1808 ng/L),并在各种患者亚组中增加了预后价值.
结论:
- GDF-15是一种新的,独立的生物标志物,用于预测NSTE-ACS患者死亡风险.
- GDF-15提供预后信息,补充了既定的临床和生化标志物.
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