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Updated: Jul 7, 2026

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Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
正常血压,高血压前期和高血压对冠状动脉微血管功能的影响
Dogan Erdogan1, Ibrahim Yildirim, Ozgur Ciftci
1Baskent University, Konya Teaching and Medical Research Center, Cardiology Department, Hoca Cihan Mah, Saray Cad, No. 1, Selcuklu, Konya, Turkey. aydoganer@yahoo.com
Circulation
|February 7, 2007
概括
冠状动脉流量储备 (CFR) 在高血压前患者中降低,这表明心血管损伤的早期迹象. 这种损伤比已确定的高血压更轻微.
科学领域:
- 心脏病学 心脏病学
- 血管生理学 血管生理学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 冠状动脉流量储备 (CFR) 通过胸前多普勒回声心脏成像进行评估,是高血压末端器官损伤的公认指标.
- 之前的研究没有评估高血压前期患者的CFR,这是高血压之前的关键阶段.
研究的目的:
- 在被诊断为高血压前患者中调查和量化冠状动脉流量储备 (CFR).
- 为了比较前高血压,已确定的高血压和健康对照之间的CFR水平.
主要方法:
- 在40名高血压前患者,60名高血压患者和50名健康对照者中,使用跨胸部多普勒回声心脏成像来测量CFR.
- 对人口,临床和生化参数进行了分析,以寻找与CFR的相似性和相关性.
主要成果:
- 与对照组相比,CFR在高血压前组显著较低 (2.54+/-0.48与2.91+/-0.53).
- 高血压组显示CFR最低 (2.23+/-0.47),高血压前期和高血压都是降低CFR的显著预测因素.
- CFR与血压,年龄,hs-CRP和心脏结构/功能参数具有反向相关性,与心脏中E/A比率具有正相关性.
结论:
- 冠状动脉流量储备 (CFR) 在患有前高血压的个体中明显受损.
- 这种损伤虽然显著,但比已确诊的高血压患者的损伤要明显,这表明前高血压是心血管损害的早期阶段.
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