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主要氨基酸和次要胺酸之间的TiIV介导反应:氨基酸形成与转氨基化相比

Denis A Kissounko1, Justin M Hoerter, Ilia A Guzei

  • 1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|February 8, 2007
PubMed
概括

(IV) 复合物介于氨基和碳胺之间的反应,产生胺或转化产物. 特定的 (IV) 复合物和反应条件决定了结果,催化 (NMe2) 4有利于选择性转米化.

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Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
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