通过对O-三氧化物进行激进关闭的碳循环化:二二化的戏剧性作用
Derrick L J Clive1, Mai P Pham, Rajendra Subedi
1Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca
Journal of the American Chemical Society
|February 8, 2007
概括
甲的O-Trityl氧化物通过激素循环化有效地形成氧化物. 这种反应利用反流四基 (THF) 中的特定试剂进行成功的合成.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 激进的反应 激进的反应
背景情况:
- O-Trityl氧化物是有机合成中的多功能中间体.
- 极端循环化反应为形成循环化合物提供了有效的途径.
- 类化物作为各种合成转化中的关键前体.
研究的目的:
- 为了研究从5-和6-二化物中衍生出的O-三氧化物的基性循环化.
- 通过激进循环化建立一种合成方法来产生氧化物.
- 探索特定试剂在促进这种转化中的实用性.
主要方法:
- 处理O-三氧化物O-三氧化物5-和6-二化物与微酸化物 (Bu3SnH).
- 作为一个激素启动剂,使用1.1'-azobis ((cyclohexanecarbonitrile) 作为激素启动剂.
- 包括N,N-二异乙烯胺 (i-Pr2NEt) 和二二化物 (PhSeSePh) 作为添加剂.
- 在四水富兰 (THF) 的反流条件下进行的反应.
主要成果:
- 甲基衍生的O-三氧化物成功的基因循环.
- 目标氧化物产品的形成.
- 在指定的条件下证明反应的有效性.
结论:
- 这项研究证明了一种可行的激素循环化方法,用于从甲的O-三氧化氧化物合成氧化物.
- 在THF中Bu3SnH,ACCN,i-Pr2NEt和PhSeSePh的组合有效地促进了循环.
- 这种方法为合成化学家的工具包构建含氧化物分子提供了宝贵的补充.
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