频率域测量心脏周期变化和心肌梗塞后死亡率
J T Bigger1, J L Fleiss, R C Steinman
1Department of Medicine, School of Public Health, Columbia University, New York, N.Y. 10032.
Circulation
|January 11, 1992
概括
心脏周期变化度,特别是超低频 (ULF) 和非常低频 (VLF) 功率,是心肌梗塞后死亡率的强有力的预测指标. 这些措施与传统的风险因素相结合,可以改善风险预测.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 临床研究 临床研究
背景情况:
- 在715名心肌梗塞后患者中,研究了心脏周期变化 (HPV) 频率域测量和死亡率之间的关联.
- 随访期为4年,以评估死亡结果.
研究的目的:
- 确定心脏周期变化 (HPV) 和死亡率的六个频率域测量之间的关联.
- 确定HPV测量对心肌梗塞后死亡率的独立预测值.
主要方法:
- 研究了心肌梗塞后两周的715名患者.
- 分析了心脏周期变化 (HPV) 的六个频域测量.
- 利用多变量考克斯回归模型,根据已确定的风险预测因素进行调整.
主要成果:
- 所有的HPV测量都显示出与所有原因,心脏和心律不整的死亡有显著的单变关联.
- 低频带 (ULF,VLF) 显示出比高频带 (LF,HF) 更强烈的关联.
- 在多变量分析中,ULF功率是死亡率最强的独立预测因素.
结论:
- 在对传统风险因素进行调整后,总体,ULF和VLF功率仍然是死亡率的重要预测因素.
- 添加到现有的预测指标时,HPV测量可以识别高风险子组,大约50%的2.5年死亡率.
- VLF功率显示出与不律性死亡的特定关联.
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