使用99mTc单克隆抗纤维素抗体进行非侵入性动脉血栓成像
M D Cerqueira1, J R Stratton, R Vracko
1Department of Medicine, University of Washington, Seattle.
Circulation
|January 1, 1992
概括
标有Technetium-99m的抗纤维素抗体碎片可以对急性动脉瘤进行成像. 这种非侵入性方法通过放射性核素成像,在形成的两小时内检测出瘤.
科学领域:
- 核医学是一种核医学.
- 心血管成像 - 心血管成像
- 免疫素图像学 免疫素图像学
背景情况:
- T2G1s单克隆抗体特别针对纤维素,纤维素是血栓的关键组成部分,但不是纤维素原.
- 准确及时检测急性动脉血栓瘤对于有效的患者管理至关重要.
研究的目的:
- 评估使用标记为technetium-99m (99mTc) 的T2G1s抗纤维素抗体Fab'片段用于成像急性动脉血栓的可行性.
- 在狗模型中评估放射标记抗体的血栓吸收的特异性和时间.
主要方法:
- 在14只狗中使用各种方法 (封闭,压伤,血栓注射) 诱导了急性动脉瘤.
- 进行了99mTc标记T2G1s抗体Fab'片段的静脉注射.
- 连续的平面放射性核素成像立即进行,并在注射后1到2小时进行,随后对抗体吸收进行了ex vivo分析.
主要成果:
- 放射性标记的抗体在瘤中表现出特定的吸收,在2小时内观察到逐渐积累.
- 活体分析证实,与相邻受伤的动脉壁和对照动脉相比,thrombi中的抗体吸收显著更高.
- 放射性核素成像成功检测到所有诱导的动脉血栓在2小时的时间点.
结论:
- 标有99mTc的T2G1s抗体Fab'片段被急性动脉血栓吸收.
- 通过这种免疫光学方法,在它们形成后2小时内可以进行非侵入性检测动脉瘤.
更多相关视频
06:46Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection
Published on: July 16, 2018
06:29Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
相关概念视频
Imaging Studies for Cardiovascular System IV: CMRI
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Imaging Studies VII: Vascular Imaging
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
