患有外周血管疾病的男性的脂蛋白概况. 中密度脂蛋白和阿波蛋白E表型的作用
M Sentí1, X Nogués, J Pedro-Botet
1Department of Medicine, Hospital del Mar, Universidad Autónoma de Barcelona, Spain.
Circulation
|January 1, 1992
概括
脂蛋白干扰,特别是中密度脂蛋白 (IDL),是外周血管疾病 (PVD) 的重要危险因素. 异常的IDL水平有助于PVD的发展和严重程度,即使在正常胆固醇的患者中也是如此.
科学领域:
- 心血管医学 心血管医学
- 脂质学 脂质学是指脂质学.
- 血管生物学 血管生物学
背景情况:
- 脂蛋白异常在外周血管疾病 (PVD) 发展中的确切作用需要进一步阐明.
- 现有研究尚未完全澄清特定脂蛋白干扰与PVD之间的关联.
研究的目的:
- 研究各种脂蛋白之间的关系,包括中间密度脂蛋白 (IDL) 和外周血管疾病 (PVD).
- 评估脂蛋白样本对PVD严重程度和正常脂质水平的患者的影响.
主要方法:
- 在102名患有PVD的男性中对脂蛋白度进行比较分析,与100名健康对照进行比较.
- 评估血清甘油三,胆固醇,非常低密度脂蛋白 (VLDL),中间密度脂蛋白 (IDL) 和高密度脂蛋白 (HDL) 的水平.
- 评估阿波蛋白E (apo E) 多态性及其对PVD患者脂质谱的影响.
主要成果:
- 与对照组相比,PVD患者表现出高水平的甘油三,VLDL胆固醇和IDL脂质,以及较低的HDL胆固醇.
- 显著的IDL异常和降低的HDL胆固醇甚至在PVD患者中观察到正常的血清胆固醇和甘油三水平.
- 增加的IDL脂质和降低的HDL胆固醇与更严重的远端PVD参与相关. 吸烟与VLDL升高和HDL降低有关.
结论:
- 脂蛋白干扰是PVD发展和进展的重要危险因素.
- 中密度脂蛋白 (IDL) 的异常在PVD病原和严重程度方面至关重要.
- 应将IDL异常视为血管风险因素,特别是在正常胆固醇和正常甘油三血症患者中.
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