突发性心脏病死亡在过度缩性心肌病症中
1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. 20892.
Circulation
|January 1, 1992
概括
过高心肌病 (HCM) 的突然死亡会影响年轻人,通常是在低功耗活动期间. 识别心律失常和家族病史等危险因素对于预防至关重要.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 突然的心脏病死亡.
背景情况:
- 突发性死亡是高伤性心肌病 (HCM) 自然史的一个重要方面.
- 了解病因和识别有风险的患者是密集研究的领域.
- 与HCM相关的突然死亡每年发生在2-3%的患者中,主要发生在老年儿童和年轻人中.
研究的目的:
- 审查过度缩性心肌病症突然死亡的性质和病因学.
- 讨论潜在的增加风险的患者的鉴定.
- 探索有关HCM和突然死亡的不断发展的概念和知识.
主要方法:
- 综述现有关于高伤性心肌病突发死亡的文献.
- 分析已识别的风险因素,包括患者人口统计,临床表现和诊断研究结果.
- 检查受影响个体的电生理学和血液动力学发现.
主要成果:
- 在HCM中突然死亡通常影响年轻,无症状的个体,左心室壁厚,通常在最低限度的体力活动中.
- 少数死亡发生在艰苦的运动期间或之后.
- 已确定的危险因素包括非持续性心室动脉冲动,家族突发死亡史和昏迷.
结论:
- 电生理学研究显示,高风险患者的鼻腔或His-Purkinje导电疾病和诱导性心律失常.
- 诱导性心室节律失常与先前昏迷或心脏骤停相关.
- 突然死亡的潜在机制包括心律失常,导电疾病,流出管道阻塞和心肌缺血.
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