相关实验视频

Updated: Jul 7, 2026

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells
13:20

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells

Published on: July 29, 2010

基因组甲基化依赖机制强加于核受体对基因激活的连接体依赖性

Ivan Garcia-Bassets1, Young-Soo Kwon2, Francesca Telese1

  • 1Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, School of Medicine 9500 Gilman Drive, La Jolla, CA 92093-0648.

Cell
|February 10, 2007
PubMed
概括

特定的基因组甲基转移酶 (HMTs) 充当守门员,防止未结合的核受体激活基因. 这种依赖于HMT的基因组代码需要基因组脱甲基酶来进行适当的基因激活,将甲基化与受调节的基因表达联系起来.

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Histone Modification02:32

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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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