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Updated: Jul 17, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

当BH3配体与多个Bcl-2同类发生接触时,而不是Bax或Bak时,便会启动亡

Simon N Willis1, Jamie I Fletcher, Thomas Kaufmann

  • 1Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

Science (New York, N.Y.)
|February 10, 2007
PubMed
概括

只有BH3的蛋白质主要通过抑制支持生存的Bcl-2蛋白来触发亡,而不是直接激活Bax和Bak. 这一发现挑战了编程细胞死亡调节的直接激活模型.

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