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Updated: Jul 12, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

最小化一个蛋白质-DNA二极化剂

Ryan L Stafford1, Hans-Dieter Arndt, Mary L Brezinski

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Journal of the American Chemical Society
|February 13, 2007
PubMed
概括

研究人员设计了一种蛋白质-DNA二分剂,以增强转录因子的结合. 修改成分,特别是托立体化学,改善了复杂的稳定性,为人工转录因子设计提供了洞察力.

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