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Updated: Jul 17, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

胎儿积症的非侵入性产前诊断

Alexandra Benachi1, Jean-Marc Costa

  • 1Université Paris-Descartes, Faculté de Médecine, AP-HP, Maternité Hôpital Necker-Enfants Malades, 75015 Paris, France. alexandra.benachi@nck.aphp.fr

Lancet (London, England)
|February 13, 2007
PubMed
概括

No abstract available in PubMed .

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Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...